Istradefylline for Parkinson's disease patients experiencing motor fluctuations: results of the KW-6002-US-018 study.
Identifieur interne : 001193 ( Main/Exploration ); précédent : 001192; suivant : 001194Istradefylline for Parkinson's disease patients experiencing motor fluctuations: results of the KW-6002-US-018 study.
Auteurs : Emmanuelle Pourcher [Canada] ; Hubert H. Fernandez ; Mark Stacy ; Akihisa Mori ; Rocco Ballerini ; Philip ChaikinSource :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2012.
English descriptors
- KwdEn :
- Adenosine A2 Receptor Antagonists (therapeutic use), Aged, Antiparkinson Agents (therapeutic use), Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged, Motor Skills (drug effects), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Purines (therapeutic use).
- MESH :
- chemical , therapeutic use : Adenosine A2 Receptor Antagonists, Antiparkinson Agents, Purines.
- drug effects : Motor Skills.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Aged, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged.
Abstract
Istradefylline (KW-6002) is a selective adenosine A(2A) receptor antagonist investigated as adjunctive therapy to levodopa in PD patients with motor response complications. In Phase 2b/3 studies, Istradefylline reduced OFF time without worsening troublesome dyskinesia and was well tolerated.
DOI: 10.1016/j.parkreldis.2011.09.023
PubMed: 22000279
Affiliations:
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Le document en format XML
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Fernandez</name></author><author><name sortKey="Stacy, Mark" sort="Stacy, Mark" uniqKey="Stacy M" first="Mark" last="Stacy">Mark Stacy</name></author><author><name sortKey="Mori, Akihisa" sort="Mori, Akihisa" uniqKey="Mori A" first="Akihisa" last="Mori">Akihisa Mori</name></author><author><name sortKey="Ballerini, Rocco" sort="Ballerini, Rocco" uniqKey="Ballerini R" first="Rocco" last="Ballerini">Rocco Ballerini</name></author><author><name sortKey="Chaikin, Philip" sort="Chaikin, Philip" uniqKey="Chaikin P" first="Philip" last="Chaikin">Philip Chaikin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22000279</idno><idno type="pmid">22000279</idno><idno type="doi">10.1016/j.parkreldis.2011.09.023</idno><idno type="wicri:Area/PubMed/Corpus">000B09</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B09</idno><idno type="wicri:Area/PubMed/Curation">000B09</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B09</idno><idno type="wicri:Area/PubMed/Checkpoint">000B09</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B09</idno><idno type="wicri:Area/Ncbi/Merge">000F79</idno><idno type="wicri:Area/Ncbi/Curation">000F79</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F79</idno><idno type="wicri:Area/Main/Merge">001217</idno><idno type="wicri:Area/Main/Curation">001193</idno><idno type="wicri:Area/Main/Exploration">001193</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Istradefylline for Parkinson's disease patients experiencing motor fluctuations: results of the KW-6002-US-018 study.</title><author><name sortKey="Pourcher, Emmanuelle" sort="Pourcher, Emmanuelle" uniqKey="Pourcher E" first="Emmanuelle" last="Pourcher">Emmanuelle Pourcher</name><affiliation wicri:level="1"><nlm:affiliation>Clinique Sainte-Anne-Laval University, 1248, Chemin Sainte-Foy, Suite # 304, Quebec, Canada. psa@riq.qc.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Clinique Sainte-Anne-Laval University, 1248, Chemin Sainte-Foy, Suite # 304, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name></author><author><name sortKey="Stacy, Mark" sort="Stacy, Mark" uniqKey="Stacy M" first="Mark" last="Stacy">Mark Stacy</name></author><author><name sortKey="Mori, Akihisa" sort="Mori, Akihisa" uniqKey="Mori A" first="Akihisa" last="Mori">Akihisa Mori</name></author><author><name sortKey="Ballerini, Rocco" sort="Ballerini, Rocco" uniqKey="Ballerini R" first="Rocco" last="Ballerini">Rocco Ballerini</name></author><author><name sortKey="Chaikin, Philip" sort="Chaikin, Philip" uniqKey="Chaikin P" first="Philip" last="Chaikin">Philip Chaikin</name></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine A2 Receptor Antagonists (therapeutic use)</term><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Dose-Response Relationship, Drug</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Skills (drug effects)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Purines (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adenosine A2 Receptor Antagonists</term><term>Antiparkinson Agents</term><term>Purines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Skills</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Dose-Response Relationship, Drug</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Istradefylline (KW-6002) is a selective adenosine A(2A) receptor antagonist investigated as adjunctive therapy to levodopa in PD patients with motor response complications. In Phase 2b/3 studies, Istradefylline reduced OFF time without worsening troublesome dyskinesia and was well tolerated.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Ballerini, Rocco" sort="Ballerini, Rocco" uniqKey="Ballerini R" first="Rocco" last="Ballerini">Rocco Ballerini</name><name sortKey="Chaikin, Philip" sort="Chaikin, Philip" uniqKey="Chaikin P" first="Philip" last="Chaikin">Philip Chaikin</name><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name><name sortKey="Mori, Akihisa" sort="Mori, Akihisa" uniqKey="Mori A" first="Akihisa" last="Mori">Akihisa Mori</name><name sortKey="Stacy, Mark" sort="Stacy, Mark" uniqKey="Stacy M" first="Mark" last="Stacy">Mark Stacy</name></noCountry><country name="Canada"><noRegion><name sortKey="Pourcher, Emmanuelle" sort="Pourcher, Emmanuelle" uniqKey="Pourcher E" first="Emmanuelle" last="Pourcher">Emmanuelle Pourcher</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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